Loading...
This record has been deleted. Since it is linked to a published record, it is available here for reference purposes only.
Click here to view the deleted recordCe document a été mis à jour. Il ne s’agit pas de la dernière version publiée. Cliquez ici pour voir la dernière version du fichier.
Élément génétique
(GENE)
last updated: 26 août 2026
Modified head involution defective Ala2
EN
-
Lucilia sericata head involution defective Ala2EN
CS-hidAla2-LUCSE
EN
Séquence codante de protéines
Oui
-
BCH-ORGA-SCBD-300803-2 Organisme Lucilia sericata (Common greenbottle fly, Sheep-strike greenbottle fly, Common European greenbottle fly)Insectes
FR
Modified Head involution defective (HID) protein
EN
The Lucilia sericata head involution defective Ala2 encodes a modified version of the Head Involution Defective (HID) protein, a pro-apoptotic factor that promotes programmed cell death (apoptosis). HID proteins promote cell death by antagonizing endogenous inhibitors of apoptosis, thereby facilitating activation of apoptotic pathways. The Ala2 variant was engineered by replacing two conserved mitogen-activated protein kinase (MAPK) phosphorylation sites with alanine residues. These substitutions were introduced to prevent phosphorylation-mediated inhibition of HID activity and enhance its effectiveness as a pro-apoptotic lethal effector.
EN
FR
